Background and Treatment

Implant and tissue infections represent a significant risk factor during the healing process after surgery or trauma and can significantly influence or delay the recovery process.

This also has an influence on patient morbidity and mortality and generates enormous costs for the public health sector worldwide.

The greatest challenges here are due, firstly, to the duration of pathogen identification and the fact that empirical treatment usually begins before the laboratory results are available, and secondly, to the increasing antibiotic resistance of bacteria in the clinical environment.

In order to fundamentally improve treatment quality in the case of implant and tissue infections, early and reliable identification of the causative pathogens is just as necessary as adequate antimicrobial treatment.

Early Detection of Biofilm Formation

Bacteria occur not only in planktonic form in blood and other bodily fluids, but they also multiply on surfaces and form what is known as a biofilm, the clinical significance of which is often underestimated. Typical biofilm-forming pathogens are:

  • Propionibacterium acnes
  • Staphylococci
  • Pseudomonas spp.
  • Candida spp.

These infections are essentially resistant to antibiotic treatment and can easily develop into a chronic state. Especially when using catheters, artificial heart valves and prostheses, a biofilm can develop, which is very difficult to treat. Here, early detection and reliable analysis are the basic requirements for successful treatment.